Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.
OBJECTIVES Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in n...
متن کاملCD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy su...
متن کاملcd226 rs763361 (gly307ser) polymorphism is associated with susceptibility to rheumatoid arthritis in zahedan, southeast iran
background: rheumatoid arthritis (ra) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. the aim of the present study was to investigate the impact of cd226 rs727088 and rs763361 polymorphisms and susceptibility to ra in a sample of the iranian population. methods: this case-control study was carried out on 100 patients with ra and 104 healthy su...
متن کاملCD226 rs763361 (Gly307Ser) polymorphism is associated with susceptibility to rheumatoid arthritis in Zahedan, southeast Iran.
BACKGROUND Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. METHODS This case-control study was carried out on 100 patients with RA and 104 healthy su...
متن کاملA Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans
CONTEXT Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions. OBJECTIVE We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD. DE...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2010
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kep470